Antioxidant status of liver, erythrocytes, and blood serum of rats in acute methanol intoxication

被引：16

作者：

Skrzydlewska, E ^{[1
]}

Farbiszewski, R ^{[1
]}

机构：

[1] MED ACAD BIALYSTOK, DEPT ANALYT CHEM, PL-15230 BIALYSTOK 8, POLAND

来源：

ALCOHOL | 1997年 / 14卷 / 05期

关键词：

antioxidant enzymes; SH groups; ascorbic acid; alpha-Tocopherol; rat;

D O I：

10.1016/S0741-8329(96)00149-8

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

SOD, CAT, GSH-Px, GSSG-R, ascorbic acid, alpha-tocopherol, nonprotein-and protein-bound sulfhydryl compounds, and TBA-rs content in the liver, erythrocytes, and blood serum of rats treated with methanol after 6, 12, and 24 h and 2, 5, and 7 days were investigated. Furthemore, hematological parameters of erythrocytes were analysed, GSH-Px, GSSG-R, sulfhydryl compounds, and ascorbic acid in the liver, erythrocytes, and in blood serum were significantly decreased. In addition, Cu,Zn SOD and tocopherol in erythrocytes were diminished, whereas TBA-rs in the three biological materials was enhanced. Simultaneously, erythrocytes amount, hemoglobin level, hematocrit, and MCV were reduced. These results indicate that methanol in rats leads to the impairment of antioxidant mechanisms in the liver, erythrocytes, and blood serum. (C) 1997 Elsevier Science Inc.

引用

页码：431 / 437

页数：7

共 30 条

[11]

HARRIS ED, 1992, FASEB J, V6, P2675, DOI 10.1096/fasebj.6.9.1612291

[12]

KAGAN VE, 1974, DOKL AKAD NAUK SSSR+, V217, P213

[13] SIMPLE COLORIMETRIC METHOD FOR ASCORBIC-ACID DETERMINATION IN BLOOD-PLASMA [J].

KYAW, A .

CLINICA CHIMICA ACTA, 1978, 86 (02) :153-157

[14] METHANOL AND FORMIC-ACID TOXICITY - BIOCHEMICAL-MECHANISMS [J].

LIESIVUORI, J ;

SAVOLAINEN, H .

PHARMACOLOGY & TOXICOLOGY, 1991, 69 (03) :157-163

[15]

MAGNANI M, 1993, BIOTECHNOL APPL BIOC, V18, P217

[16]

McCord J.M., 1972, J BIOL CHEM, V247, P6960

[17] METHANOL POISONING .1. ROLE OF FORMIC-ACID IN DEVELOPMENT OF METABOLIC-ACIDOSIS IN MONKEY AND REVERSAL BY 4-METHYLPYRAZOLE [J].

MCMARTIN, KE ;

MAKAR, AB ;

MARTIN, G ;

PALESE, M ;

TEPHLY, TR .

BIOCHEMICAL MEDICINE, 1975, 13 (04) :319-333

[18] SELECTIVE MODIFICATION OF GLUTATHIONE METABOLISM [J].

MEISTER, A .

SCIENCE, 1983, 220 (4596) :472-477

[19]

MINOTTI G, 1987, J BIOL CHEM, V262, P1098

[20]

MISRA HP, 1972, J BIOL CHEM, V247, P3170

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