Ruthenium N-heterocyclic carbene catalysts for selective reduction of nitriles to primary amines

被引：74

作者：

Addis, Daniele ^{[1
]}

Enthaler, Stephan ^{[1
]}

Junge, Kathrin ^{[1
]}

Wendt, Bianca ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse EV, D-18059 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 26期

关键词：

Homogeneous catalysis; Hydrogenation; Nitriles; Primary amines; Ruthenium; PALLADIUM-CARBENE; SUZUKI-MIYAURA; ARYL HALIDES; POTASSIUM HEXACYANOFERRATE(II); COUPLING REACTIONS; BUCHWALD-HARTWIG; CYANATION; COMPLEXES; EFFICIENT; HYDROAMINOMETHYLATION;

D O I：

10.1016/j.tetlet.2009.03.108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Easily accessible in situ catalysts composed of [Ru(cod)(2-methylallyl)(2)] and N-heterocyclic carbene ligands have been developed for the environmentally benign hydrogenation of various nitriles to give primary amines. Applying optimized conditions in the presence of SIMesBF(4) as ligand high catalyst activity of up to 392 h(-1) is achieved in the hydrogenation of benzonitrile. The general applicability and functional group tolerance of this novel catalyst system are shown in the reduction of ten different nitriles. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3654 / 3656

页数：3

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