Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography

被引:59
作者
Tao, Yuankai K. [1 ]
Kennedy, Kristen M. [1 ]
Izatt, Joseph A. [1 ]
机构
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
来源
OPTICS EXPRESS | 2009年 / 17卷 / 05期
关键词
FULL-RANGE; BLOOD-FLOW; HIGH-SPEED; DOPPLER; RESOLUTION;
D O I
10.1364/OE.17.004177
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We demonstrate in vivo velocity-resolved, volumetric bidirectional blood flow imaging in human retina using single-pass flow imaging spectral domain optical coherence tomography (SPFI-SDOCT). This technique uses previously described methods for separating moving and non-moving scatterers within a depth by using a modified Hilbert transform. Additionally, a moving spatial frequency window is applied, creating a stack of depth-resolved images of moving scatterers, each representing a finite velocity range. The resulting velocity reconstruction is validated with and strongly correlated to velocities measured with conventional Doppler OCT in flow phantoms. In vivo velocity-resolved flow mapping is acquired in healthy human retina and demonstrate the measurement of vessel size, peak velocity, and total foveal blood flow with OCT. (C) 2009 Optical Society of America
引用
收藏
页码:4177 / 4188
页数:12
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