Novel DNA damage mediated by oxidation of various modified nucleotide residues

被引：5

作者：

Inoue, H

Koizume, S

Yamauchi, T

Murata, K

Ohtsuka, E

机构：

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Permanganate reaction of DNA oligomers containing an 8-oxoadenine or 5-hydroxyuracil residue was studied, and the results were compared with those for an 8-oxoguanine-containing oligomers. We obtained similar results and found that the nucleotide residues neighboring the modified base were damaged and that the novel damage was induced by the oxidation of the modified base.

引用

页码：1489 / 1490

页数：2

共 6 条

[1] 8-HYDROXYADENINE (7,8-DIHYDRO-8-OXOADENINE) INDUCES MISINCORPORATION IN IN-VITRO DNA-SYNTHESIS AND MUTATIONS IN NIH 3T3 CELLS
KAMIYA, H
MIURA, H
MURATAKAMIYA, N
ISHIKAWA, H
SAKAGUCHI, T
INOUE, H
SASAKI, T
MASUTANI, C
HANAOKA, F
NISHIMURA, S
OHTSUKA, E
[J]. NUCLEIC ACIDS RESEARCH, 1995, 23 (15) : 2893 - 2899
[2] 8-HYDROXYGUANINE (7,8-DIHYDRO-8-OXOGUANINE) IN HOT-SPOTS OF THE C-HA-RAS GENE - EFFECTS OF SEQUENCE CONTEXTS ON MUTATION SPECTRA
KAMIYA, H
MURATAKAMIYA, N
KOIZUME, S
INOUE, H
NISHIMURA, S
OHTSUKA, E
[J]. CARCINOGENESIS, 1995, 16 (04) : 883 - 889
[3] SYNTHESIS AND THERMODYNAMIC STABILITIES OF DAMAGED DNA INVOLVING 8-HYDROXYGUANINE (7,8-DIHYDRO-8-OXOGUANINE) IN A RAS-GENE FRAGMENT
KOIZUME, S
KAMIYA, H
INOUE, H
OHTSUKA, E
[J]. NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (6-7): : 1517 - 1534
[4] Novel DNA damage mediated by oxidation of an 8-oxoguanine residue
Koizume, S
Inoue, H
Kamiya, H
Ohtsuka, E
[J]. CHEMICAL COMMUNICATIONS, 1996, (02) : 265 - 266
[5] MCCARTHY JG, 1989, NUCLEIC ACIDS RES, V18, P7541
[6] YANAGAWA H, 1992, J BIOL CHEM, V267, P13320

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