Synthesis and reactions of fluoroether anesthetics

被引：18

作者：

Ramig, K ^{[1
]}

机构：

[1] CUNY Bernard M Baruch Coll, Dept Nat Sci, New York, NY 10010 USA

来源：

SYNTHESIS-STUTTGART | 2002年 / 17期

关键词：

fluorine; halogenation; drugs; halogenated ethers; halogen-exchange fluorination;

D O I：

10.1055/s-2002-35633

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New and recent work by the author and colleagues Will be presented. Six methods for functionalizing halogenated ethers will be presented: (1) a new regent for halogen-exchange fluorination of chloromethyl ethers, (2) a selective photochemical or thermal reduction of poly-chlorinated substrates, (3) new organic sources of fluoride for antimony-pentachloride-catalyzed halogen-exchange fluorination, (4) a chemoselective methanolysis reaction of the trifluoromethyl group, (5) a stereoselective decarboxylation reaction, and (6) the use of bromine trifluoride for fluorination with inversion of configuration. The reactions are applied to the synthesis of individual enantiomers of fluoroether anesthetics.

引用

页码：2627 / 2631

页数：5

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