Role of DBP in the circadian oscillatory mechanism

被引：202

作者：

Yamaguchi, S ^{[1
]}

Mitsui, S ^{[1
]}

Yan, LL ^{[1
]}

Yagita, K ^{[1
]}

Miyake, S ^{[1
]}

Okamura, H ^{[1
]}

机构：

[1] Kobe Univ, Sch Med, Dept Anat & Brain Sci, Chuo Ku, Kobe, Hyogo 6500017, Japan

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2000年 / 20卷 / 13期

关键词：

D O I：

10.1128/MCB.20.13.4773-4781.2000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcript levels of DBP, a member of the PAR leucine zipper transcription factor family, exhibit a robust rhythm in suprachiasmatic nuclei, the mammalian circadian center. Here we report that DBP is able to activate the promoter of a putative clock oscillating gene, mPer1, by directly binding to the mPer1 promoter. The mPer1 promoter is cooperatively activated by DBP and CLOCK-BMAL1. On the other hand, dbp transcription is activated by CLOCK-BMAL1 through E-boxes and inhibited by the mPER and mCRY proteins, as is the case for mPer1. Thus, a clock-controlled dbp gene may play an important role in central clock oscillation.

引用

页码：4773 / 4781

页数：9

共 36 条

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