Expanding the organismal scope of proteomics: Cross-species protein identification by mass spectrometry and its implications

被引:156
作者
Liska, AJ [1 ]
Shevchenko, A [1 ]
机构
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
关键词
functional genomics; genomics; mass spectrometry; phylogenetics; protein complexes; review;
D O I
10.1002/pmic.200390004
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Due to the limited applicability of conventional protein identification methods to the proteomes of organisms with unsequenced genomes, researchers have developed approaches to identify proteins using mass spectrometry and sequence similarity database searches. Both the integration of mass spectrometry with bioinformatics and genomic sequencing drive the expanding organismal scope of proteomics.
引用
收藏
页码:19 / 28
页数:10
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