Basic mechanisms of gabitril (tiagabine) and future potential developments

被引：73

作者：

Meldrum, BS ^{[1
]}

Chapman, AG ^{[1
]}

机构：

[1] Univ London Kings Coll, Inst Psychiat, Dept Clin Neurosci, London SE5 8AF, England

来源：

EPILEPSIA | 1999年 / 40卷

关键词：

epilepsy; tiagabine; antiepileptic; GABA; mode of action;

D O I：

10.1111/j.1528-1157.1999.tb02087.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gabitril (tiagabine) is a potent selective inhibitor of the principal neuronal gamma-aminobutyric acid (GABA) transporter (GAT-1) in the cortex and hippocampus. By slowing the reuptake: of synaptically-released GABA, it prolongs inhibitory postsynaptic potentials. In animal models of epilepsy, tiagabine is particularly effective against kindled (limbic) seizures and against reflexly-induced generalized convulsive seizures. These data are predictive of its efficacy in complex partial seizures in humans. Possible clinical applications outside the field of epilepsy include bipolar disorder and pain.

引用

页码：S2 / S6

页数：5

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