Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery

被引：21

作者：

Chen, Daquan ^{[1
]}

Yu, Hongyun ^{[1
]}

Mu, Hongjie ^{[1
,2
]}

Li, Guisheng ^{[1
,2
]}

Shen, Yan ^{[3
]}

机构：

[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China

[2] State Key Lab Long Acting & Targeting Drug Delive, Yantai, Peoples R China

[3] China Pharmaceut Univ, Coll Pharm, Nanjing, Jiangsu, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2014年 / 42卷 / 03期

关键词：

double pH-sensitive; Ginsenoside Rh2 delivery; mixed micelles; multicore niosomes; POLYKETAL MICROPARTICLES; LIPOSOME; NANOPARTICLES;

D O I：

10.3109/21691401.2013.794358

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

In this study, we report the novel double pH-sensitive mixed micelles to fabricate multicore niosomes for drug delivery. The double pH-sensitive mixed micelles (PMM) were prepared with different pH-sensitive polymers, mPEG2000-Hz-CHEMS and mPEG2000-IS (2:1 w/w). Ginsenoside Rh2-loaded DPMM was mixed with Pluronic F-68, in the aqueous medium, and multicore niosomes were fabricated. The size of multicore niosomes were around 100-300 nm with a high encapsulation efficiency of G-Rh2. The G-Rh2-MCN could release encapsulated G-Rh2 with an accelerated rate under lower pH conditions with lower cytotoxicity and good antitumor efficacy.

引用

收藏

页码：205 / 209

页数：5

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