Synthesis and anticancer activity of cyclopalladated complexes containing 4-hydroxy-acridine

被引:39
作者
Pucci, Daniela [1 ]
Albertini, Veronica
Bloise, Rossana
Bellusci, Anna
Cataldi, Antonella
Catapano, Carlo V.
Ghedini, Mauro
Crispini, Alessandra
机构
[1] Univ Calabria, Dipartimento Chim, CR INSTM Unita Calabria, Ctr Eccellenza,CEMIF,CAL,LASCAMM, Calabria, Italy
[2] Oncol Inst So Switzerland, IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland
关键词
cyclopalladated complexes; 4-hydroxyacridine; X-ray crystal structure; phenylpyridine; phenylpyrimidine;
D O I
10.1016/j.jinorgbio.2006.04.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The synthesis and the characterization (elemental analysis, H-1 NMR and X-ray) of the first cyclopalladated complexes containing 4-hydroxyacridinate as complementary ligand are described. 4-Hydroxyacridine acts as a bidentate [N,O] chelating ligand, giving rise to square planar Pd(II) complexes in the coordination of a cyclopalladated fragment of phenylpyridine or phenylpyrimidine, characterized by the presence of two almost coplanar metalated rings. The biological activity studies conducted on these new Pd(II) complexes proved that the phenylpyridine Pd(II) derivative is more efficient than cis-platinum. The intrinsically substitutional inertness of the cyclopalladated ring and the presence of the [N,O] chelated acridine ligand make these systems of particular interest in their promising biological activity. (c) 2006 Published by Elsevier Inc.
引用
收藏
页码:1575 / 1578
页数:4
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