Biological screening of Amaranthus retroflexus L. (Amaranthaceae)

被引：11

作者：

Amoli, Jamileh Salar ^{[1
]}

Sadighara, Parisa ^{[1
]}

Barin, Abbas ^{[2
]}

Yazdani, Azam ^{[3
]}

Satari, Saeed

机构：

[1] Univ Tehran, Dept Toxicol, Fac Vet, Tehran, Iran

[2] Univ Tehran, Dept Clin Pathol, Fac Vet, Tehran, Iran

[3] Univ Tehran, Dept Poultry, Fac Vet, Tehran, Iran

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2009年 / 19卷 / 2B期

关键词：

Amaranthus retroflexus; Amaranthaceae; brine shrimp lethality assay; MTT assay; BIOACTIVITY; CATTLE; BRAZIL;

D O I：

10.1590/S0102-695X2009000400019

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Bioassays are required for the determination of the total toxicity of Amaranthus retroflexus L. (Amaranthaceae) or "redroot pigweed". Therefore, the plant extract has been tested for bioactivity in Artemia salina and cytotoxicity against bovine kidney for cells. The LD(50) values for Artemia salina were measured at 1700 ppm. The bovine kidney cells were exposed to various concentrations of the plant extracts (100 ppm-0.1 ppm). After treating with 100 and 0.1 ppm for 24 h, the cells viability were reduced by about 49% and 35% respectively in MTT viability assay. The study confirmed that Amaranthus retroflexus has a cytotoxic effect and more specific to renal cells.

引用

页码：617 / 620

页数：4

共 19 条

[1]

Screening of antifungal activity of plants from the northeast of Mexico [J].