Bacterial nucleoid-associated proteins, nucleoid structure and gene expression

被引：647

作者：

Dillon, Shane C. ^{[1
]}

Dorman, Charles J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Moyne Inst Prevent Med, Dept Microbiol, Sch Genet & Microbiol, Dublin 2, Ireland

来源：

NATURE REVIEWS MICROBIOLOGY | 2010年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

ENTERICA SEROVAR TYPHIMURIUM; INTEGRATION HOST FACTOR; HISTONE-LIKE PROTEINS; DNA-BINDING PROTEIN; H-NS FAMILY; RESPONSIVE REGULATORY PROTEIN; ESCHERICHIA-COLI CHROMOSOME; BACILLUS-SUBTILIS LRPC; STABLE RNA PROMOTER; SALMONELLA-ENTERICA;

D O I：

10.1038/nrmicro2261

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Emerging models of the bacterial nucleoid show that nucleoid-associated proteins (NAPs) and transcription contribute in combination to the dynamic nature of nucleoid structure. NAPs and other DNA-binding proteins that display gene-silencing and anti-silencing activities are emerging as key antagonistic regulators of nucleoid structure. Furthermore, it is becoming clear that the boundary between NAPs and conventional transcriptional regulators is quite blurred and that NAPs facilitate the evolution of novel gene regulatory circuits. Here, NAP biology is considered from the standpoints of both gene regulation and nucleoid structure.

引用

页码：185 / 195

页数：11