Pepsinogen C gene product is a possible growth factor during gastric mucosal healing

被引：19

作者：

Kishi, K

Kinoshita, Y

Matsushima, Y

Okada, A

Maekawa, T

Kawanami, C

Watanabe, N

Chiba, T

机构：

[1] KYOTO UNIV, GRAD SCH MED, DEPT MED, DIV GASTROENTEROL & HEPATOL, KYOTO 606, JAPAN

[2] KOBE UNIV, SCH MED, DEPT MED, DIV GERONTOL, KOBE, HYOGO 650, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 238卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We isolated, by the subtraction cloning method, a pepsinogen C (PGC) gene fragment (the sequence between the 968th and 1179th base pairs) from a rat gastric mucosal cDNA library as a cDNA clone encoding a substance that promotes growth of the normal rat gastric mucosal cell line RGM1. Northern blot analysis revealed that PG;C gene expression was enhanced not only in acetic acid-induced chronic gastric ulcers but also in indomethacin-induced gastric mucosal lesions. PGC gene expression was also increased in the Helicobacter felis-infected stomachs. Thus, the PGC gene may play a role in gastric epithelial cell growth during gastric mucosal healing. (C) 1997 Academic Press.

引用

页码：17 / 20

页数：4

共 13 条

[1]

RELATIONSHIP OF HELICOBACTER-PYLORI TO SERUM PEPSINOGENS IN AN ASYMPTOMATIC JAPANESE POPULATION [J].