Effect of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells

被引：3

作者：

Cui, LX ^{[1
]}

Faraj, A ^{[1
]}

Sommadossi, JP ^{[1
]}

机构：

[1] Univ Alabama, Ctr Liver, Div Clin Pharmacol, Dept Pharmacol & Toxicol, Birmingham, AL 35294 USA

来源：

ANTIVIRAL RESEARCH | 1999年 / 43卷 / 03期

关键词：

D-FEAU; mitochondrial function; hepatitis B; hepatotoxicity;

D O I：

10.1016/S0166-3542(99)00050-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil (D-FEAU) on mitochondrial functions were examined in HepG2 cells. D-FEAU between 0.1 and 10 mu M had no apparent inhibitory effect on cell proliferation for 2-week period; however, D-FEAU caused a decrease in mitochondrial DNA (mtDNA) content in a dose-dependent manner with an IC50 value of 2.7 mu M. A 20.9% of increase in lactic acid production was observed after the cells were incubated with 10 mu M of D-FEAU for 4 days without substantial effect being detected at 0.1 and 1 mu M. In addition, no significant changes on mitochondrial morphology were observed in the cells treated with 10 mu M of D-FEAU for 14 days under the electron microscope. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：201 / 207

页数：7

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