Silver salt-promoted direct cross-coupling reactions of alkynylsilanes with aryl iodides: synthesis of aryl-substituted alkynylamides

被引：66

作者：

Koseki, Y ^{[1
]}

Omino, K ^{[1
]}

Anzai, S ^{[1
]}

Nagasaka, T ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 14期

关键词：

alkynes; coupling reactions; silicon and compounds; palladium catalyst;

D O I：

10.1016/S0040-4039(00)00167-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct cross-coupling reaction of 5-trimethylsilyl-4-pentynamides (alkynylsilanes) 1 with aryl iodides, promoted by silver carbonate in the presence of palladium catalyst, afforded aryl-substituted alkynylamides 2, which readily underwent cyclization to form benzylidenelactams 3. This coupling reaction proved to be a useful for synthesis of aryl-substituted alkynes. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2377 / 2380

页数：4

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