Plasma Polyunsaturated Fatty Acids and Age-Related Physical Performance Decline

被引：63

作者：

Abbatecola, Angela M.

Cherubini, Antonio ^{[2
]}

Guralnik, Jack M. ^{[3
]}

Lacueva, Cristina Andres ^{[4
]}

Ruggiero, Carmelinda ^{[2
]}

Maggio, Marcello ^{[5
]}

Bandinelli, Stefania ^{[6
]}

Paolisso, Giuseppe ^{[1
]}

Ferrucci, Luigi ^{[7
]}

机构：

[1] Univ Naples 2, Dept Geriatr Med & Metab Dis, Div Med Interna 4, I-80138 Naples, Italy

[2] Univ Perugia, Dept Clin & Expt Med, Inst Gerontol & Geriatr, Perugia, Italy

[3] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[4] Univ Barcelona, CeRTA, Dept Nutr & Food Sci, E-08007 Barcelona, Spain

[5] Univ Parma, Sect Geriatr, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy

[6] Azienda Sanit Firenze, Florence, Italy

[7] NIA, Longitudinal Studies Sect, Baltimore, MD 21224 USA

来源：

REJUVENATION RESEARCH | 2009年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

OLDER PERSONS; N-3; HEALTH; QUESTIONNAIRE; DISABILITY; VALIDITY; CANCER; BLOOD; RISK; DIET;

D O I：

10.1089/rej.2008.0799

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Due to supporting evidence that dietary patterns may have a significant role in the maintenance of good physical performance with aging, we tested whether plasma fatty acids, saturated fatty acids (SFA), and polyunsaturated (PUFA) fatty acids are cross-sectionally associated with different physical performance and predict changes in physical performance over a 3-year period. Data were from the InCHIANTI study, a population-based study of older Italians. Plasma fatty acids were measured at enrollment (1998-2000), and outcome variables, Summary Physical Performance Battery (SPPB), and time to walk 7 meters (m) were measured at enrollment and after 3 years (2001-2004). At enrollment, 330 participants had significantly impaired lower extremity performance (defined as a SPPB score <= 9). Adjusting for age, participants with a SPPB score >9 had higher levels of total PUFA, n-3 PUFA, and n-6 PUFA, while significantly lower levels of SFA than those with a SPPB score <9. Baseline SPPB scores were also associated with n-3 PUFA (beta = 0.148, p = 0.031), whereas the 7-m walk time was associated with total PUFA (beta = -0.068, p = 0.008), after adjusting for potential confounders. Of the 884 participants with a SPPB score >9 at baseline, 114 (12.9%) developed impaired lower extremity performance (SPPB <= 9). In fully adjusted logistic models, baseline n-3 PUFA levels were inversely related to the risk of developing a decline in SPPB to >9 (odds ratio [OR] = 0.21; 95% confidence interval [CI] = 0.08-0.53), while the n-6/n-3 ratio was associated with a higher risk of SPPB decline to <= 9 (OR = 5.23; 95% CI = 2.02-13.51). In multivariate regression models, the n-6/n-3 ratio was associated with a longer time to walk 7 m (beta = 0.396, p = 0.037). n-3 PUFA plasma levels, which most likely reflect dietary intake, seem to protect against accelerated decline of physical performance. A higher n-6/n-3 ratio was associated with higher risk of developing poor physical performance and slower walking speed.

引用

页码：25 / 32

页数：8

共 33 条

[31] Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer [J].