mRNA export: the long and winding road

被引:25
作者
Cole, CN [1 ]
机构
[1] Dartmouth Med Sch, Dept Biochem, Hanover, NH 03755 USA
关键词
D O I
10.1038/35008681
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
To the growing list of factors required for the export of messenger RNA from nucleus to cytoplasm can now be added Yra1. Yeast Yra1 and its metazoan orthologues bind mRNAs and interact with multiple mRNA export factors. Transport of proteins and small RNAs does not require Yra1 or any other proteins required for mRNA export, suggesting that mRNA export may proceed by a different mechanism. The finding that Yra1 has a role in mRNA export moves us one step closer to identifying all the proteins required for this process.
引用
收藏
页码:E55 / E58
页数:4
相关论文
共 18 条
  • [1] The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates
    Bachi, A
    Braun, IC
    Rodrigues, JP
    Panté, N
    Ribbeck, K
    Von Kobbe, C
    Kutay, U
    Wilm, M
    Görlich, D
    Carmo-Fonseca, M
    Izaurralde, E
    [J]. RNA, 2000, 6 (01) : 136 - 158
  • [2] Functional characterization of a Nup159p-containing nuclear pore subcomplex
    Belgareh, N
    Snay-Hodge, C
    Pasteau, F
    Dagher, S
    Cole, CN
    Doye, V
    [J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) : 3475 - 3492
  • [3] ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCR alpha enhancer function
    Bruhn, L
    Munnerlyn, A
    Grosschedl, R
    [J]. GENES & DEVELOPMENT, 1997, 11 (05) : 640 - 653
  • [4] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
    Gruter, P
    Tabernero, C
    von Kobbe, C
    Schmitt, C
    Saavedra, C
    Bachi, A
    Wilm, M
    Felber, BK
    Izaurralde, E
    [J]. MOLECULAR CELL, 1998, 1 (05) : 649 - 659
  • [5] Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells
    Hodge, CA
    Colot, HV
    Stafford, P
    Cole, CN
    [J]. EMBO JOURNAL, 1999, 18 (20) : 5778 - 5788
  • [6] The DExH protein NPH-II is a processive and directional motor for unwinding RNA
    Jankowsky, E
    Gross, CH
    Shuman, S
    Pyle, AM
    [J]. NATURE, 2000, 403 (6768) : 447 - 451
  • [7] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
    Katahira, J
    Strässer, K
    Podtelejnikov, A
    Mann, M
    Jung, JU
    Hurt, E
    [J]. EMBO JOURNAL, 1999, 18 (09) : 2593 - 2609
  • [8] Transport of proteins and RNAs in and out of the nucleus
    Nakielny, S
    Dreyfuss, G
    [J]. CELL, 1999, 99 (07) : 677 - 690
  • [9] The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
    Neville, M
    Rosbash, M
    [J]. EMBO JOURNAL, 1999, 18 (13) : 3746 - 3756
  • [10] Portman DS, 1997, RNA, V3, P527