JANUS WEDGES: A new approach towards nucleobase-pair recognition

被引：51

作者：

Branda, N ^{[1
]}

Kurz, G ^{[1
]}

Lehn, JM ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR STRASBOURG 1, URA 422, LAB CHIM SUPRAMOL, INST BEL, F-67000 STRASBOURG, FRANCE

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 21期

关键词：

D O I：

10.1039/cc9960002443

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The two-faced JANUS-type heterocycles la and Ib are designed to recognize a cytosine-uracil mismatched basepair by insertion in a wedge-like fashion between the bases to give a triad moth utilizing the maximum number of Watson-Crick interactions, as shown by H-1 NMR spectroscopic studies.

引用

页码：2443 / 2444

页数：2

共 17 条

[1] AN INVERTED MOTIF FOR OLIGONUCLEOTIDE TRIPLEXES - ADENOSINE PSEUDOURIDINE ADENOSINE (A-PSI-A) [J].

BANDARU, R ;

HASHIMOTO, H ;

SWITZER, C .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (04) :786-787

[2] 2ND STRUCTURAL MOTIF FOR RECOGNITION OF DNA BY OLIGONUCLEOTIDE-DIRECTED TRIPLE-HELIX FORMATION [J].

BEAL, PA ;

DERVAN, PB .

SCIENCE, 1991, 251 (4999) :1360-1363

[3] MOLECULAR-STRUCTURE OF THE G-A BASE PAIR IN DNA AND ITS IMPLICATIONS FOR THE MECHANISM OF TRANSVERSION MUTATIONS [J].

BROWN, T ;

HUNTER, WN ;

KNEALE, G ;

KENNARD, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2402-2406

[4] SITE-SPECIFIC OLIGONUCLEOTIDE BINDING REPRESSES TRANSCRIPTION OF THE HUMAN C-MYC GENE INVITRO [J].

COONEY, M ;

CZERNUSZEWICZ, G ;

POSTEL, EH ;

FLINT, SJ ;

HOGAN, ME .

SCIENCE, 1988, 241 (4864) :456-459

[5] CRYSTAL-STRUCTURE OF AN RNA DOUBLE HELIX INCORPORATING A TRACK OF NON-WATSON-CRICK BASE-PAIRS [J].

HOLBROOK, SR ;

CHEONG, CJ ;

TINOCO, I ;

KIM, SH .

NATURE, 1991, 353 (6344) :579-581

[6] EFFECT OF SUBSTITUENTS ON HYDROGEN BONDING OF ADENINE AND URACIL DERIVATIVES [J].

KYOGOKU, Y ;

LORD, RC ;

RICH, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 57 (02) :250-&

[7] AN INFRARED STUDY OF HYDROGEN-BONDING SPECIFICITY OF HYPOXANTHINE AND OTHER NUCLEIC ACID DERIVATIVES [J].

KYOGOKU, Y ;

LORD, RC ;

RICH, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 179 (01) :10-&

[8] SEQUENCE-TARGETED CHEMICAL MODIFICATIONS OF NUCLEIC-ACIDS BY COMPLEMENTARY OLIGONUCLEOTIDES COVALENTLY LINKED TO PORPHYRINS [J].

LEDOAN, T ;

PERROUAULT, L ;

CHASSIGNOL, M ;

THUONG, NT ;

HELENE, C .

NUCLEIC ACIDS RESEARCH, 1987, 15 (21) :8643-8659

[9] JANUS MOLECULES - SYNTHESIS OF DOUBLE-HEADED HETEROCYCLES CONTAINING 2 IDENTICAL HYDROGEN-BONDING ARRAYS [J].

MARSH, A ;

NOLEN, EG ;

GARDINIER, KM ;

LEHN, JM .

TETRAHEDRON LETTERS, 1994, 35 (03) :397-400

[10] SEQUENCE-SPECIFIC CLEAVAGE OF DOUBLE HELICAL DNA BY TRIPLE HELIX FORMATION [J].

MOSER, HE ;

DERVAN, PB .

SCIENCE, 1987, 238 (4827) :645-650

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