Inhibition of IL-12 signaling Stat4/IFN-γ pathway by rapamycin is associated with impaired dendritc cell function

被引：25

作者：

Chiang, PH ^{[1
]}

Wang, L ^{[1
]}

Liang, Y ^{[1
]}

Liang, X ^{[1
]}

Qian, S ^{[1
]}

Fung, JJ ^{[1
]}

Bonham, CA ^{[1
]}

Lu, L ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, BST, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15261 USA

来源：

TRANSPLANTATION PROCEEDINGS | 2002年 / 34卷 / 05期

关键词：

D O I：

10.1016/S0041-1345(02)02900-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：1394 / 1395

页数：2

共 6 条

[1] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[2] Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses [J].

Fukao, T ;

Frucht, DM ;

Yap, G ;

Gadina, M ;

O'Shea, JJ ;

Koyasu, S .

JOURNAL OF IMMUNOLOGY, 2001, 166 (07) :4446-4455

[3] Rapamune® (RAPA, rapamycin, sirolimus):: Mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression [J].

Sehgal, SN .

CLINICAL BIOCHEMISTRY, 1998, 31 (05) :335-340

[4] In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas [J].

Sousa, CRE ;

Hieny, S ;

SchartonKersten, T ;

Jankovic, D ;

Charest, H ;

Germain, RN ;

Sher, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (11) :1819-1829

[5] IL-12/IL-18-dependent IFN-γ release by murine dendritic cells [J].

Stober, D ;

Schirmbeck, R ;

Reimann, J .

JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :957-965

[6] Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages [J].

Woltman, AM ;

de Fijter, JW ;

Kamerling, SWA ;

van der Kooij, SW ;

Paul, LC ;

Daha, MR ;

van Kooten, C .

BLOOD, 2001, 98 (01) :174-180

← 1 →