Acute myocardial infarction and heart failure: Role of apoptosis

被引：152

作者：

Abbate, Antonio ^{[1
]}

Bussani, Rossana

Amin, Mitesh S.

Vetrovec, George W.

Baldi, Alfonso

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23284 USA

[2] Univ Trieste, Inst Pathol Anat, I-34127 Trieste, Italy

[3] Univ Naples 2, Dept Biochem, Sect Pathol, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2006年 / 38卷 / 11期

关键词：

apoptosis; heart failure; cardiac remodelling; therapy;

D O I：

10.1016/j.biocel.2006.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is a key pathologic feature in acute myocardial infarction and heart failure. Experimental animal studies have shown beneficial effects of inhibiting apoptosis. Understanding the mechanisms involved in the apoptotic cascade may be useful in better understanding of heart failure and its management. Not only in vivo detection of apoptosis may prove clinically useful in the diagnosis and risk stratification of patients with ischemic heart disease, but anti-apoptotic treatments (specific and non-specific) may be effective in the prevention and treatment of post-infarction remodelling and heart failure. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1834 / 1840

页数：7

相关论文

共 31 条

[1] Increased myocardial apoptosis in patients with unfavorable left ventricular remodeling and early symptomatic post-infarction heart failure [J].

Abbate, A ;

Biondi-Zoccai, GGL ;

Bussani, R ;

Dobrina, A ;

Camilot, D ;

Feroce, F ;

Rossiello, R ;

Baldi, F ;

Silvestri, F ;

Biasucci, LM ;

Baldi, A .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (05) :753-760

[2] Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling [J].

Abbate, A ;

Biondi-Zoccai, GGL ;

Baldi, A .

JOURNAL OF CELLULAR PHYSIOLOGY, 2002, 193 (02) :145-153

[3]

ABBATE A, 2006, APOPTOSIS 0314

[4]

ABBATE A, 2006, INT J CARDIOL 1206

[5] Apoptosis and post-infarction left ventricular remodeling [J].

Baldi, A ;

Abbate, A ;

Bussani, R ;

Patti, G ;

Melfi, R ;

Angelini, A ;

Dobrina, A ;

Rossiello, R ;

Silvestri, F ;

Baldi, F ;

Di Sciascio, G .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (02) :165-174

[6] Caspase-3 inhibition preserves myocardial geometry and long-term function after infarction [J].

Balsam, LB ;

Kofidis, T ;

Robbins, RC .

JOURNAL OF SURGICAL RESEARCH, 2005, 124 (02) :194-200

[7] Evidence that human cardiac myocytes divide after myocardial infarction (Publication with Expression of Concern. See vol. 379, pg. 1870, 2018) [J].

Beltrami, AP ;

Urbanek, K ;

Kajstura, J ;

Yan, SM ;

Finato, N ;

Bussani, R ;

Nadal-Ginard, B ;

Silvestri, F ;

Leri, A ;

Beltrami, CA ;

Anversa, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (23) :1750-1757

[8] Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction [J].

Chandrashekhar, Y ;

Sen, S ;

Anway, R ;

Shuros, A ;

Arland, I .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (02) :295-301

[9] Early anti-apoptosis treatment reduces myocardial infarct size after a prolonged reperfusion [J].

Gao, F ;

Tao, L ;

Yan, W ;

Gao, E ;

Liu, HR ;

Lopez, BL ;

Christopher, TA ;

Ma, XL .

APOPTOSIS, 2004, 9 (05) :553-559

[10] Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction - The COMplement inhibition in myocardial infarction treated with angioplasty (COMMA) trial [J].

Granger, CB ;

Mahaffey, KW ;

Weaver, WD ;

Theroux, P ;

Hochman, JS ;

Filloon, TG ;

Rollins, S ;

Todaro, TG ;

Nicolau, JC ;

Ruzyllo, W ;

Armstrong, PW .

CIRCULATION, 2003, 108 (10) :1184-1190

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