Acute myocardial infarction and heart failure: Role of apoptosis

被引：152

作者：

Abbate, Antonio ^{[1
]}

Bussani, Rossana

Amin, Mitesh S.

Vetrovec, George W.

Baldi, Alfonso

机构：

[1] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA 23284 USA

[2] Univ Trieste, Inst Pathol Anat, I-34127 Trieste, Italy

[3] Univ Naples 2, Dept Biochem, Sect Pathol, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2006年 / 38卷 / 11期

关键词：

apoptosis; heart failure; cardiac remodelling; therapy;

D O I：

10.1016/j.biocel.2006.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is a key pathologic feature in acute myocardial infarction and heart failure. Experimental animal studies have shown beneficial effects of inhibiting apoptosis. Understanding the mechanisms involved in the apoptotic cascade may be useful in better understanding of heart failure and its management. Not only in vivo detection of apoptosis may prove clinically useful in the diagnosis and risk stratification of patients with ischemic heart disease, but anti-apoptotic treatments (specific and non-specific) may be effective in the prevention and treatment of post-infarction remodelling and heart failure. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1834 / 1840

页数：7

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