Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody

被引：56

作者：

Abdel-Motal, Ussama M. ^{[1
]}

Wigglesworth, Kim ^{[1
]}

Galili, Uri ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Surg, Worcester, MA 01655 USA

来源：

VACCINE | 2009年 / 27卷 / 23期

关键词：

Vaccine; alpha-Gal glycolipids; Anti-Gal antibody; APC; ALPHA-GALACTOSYL EPITOPES; DENDRITIC CELLS; T-CELLS; CROSS-PRESENTATION; PRESENTING CELLS; VIRUS-VACCINE; EXPRESSION; RESPONSES; TUMOR; IGG;

D O I：

10.1016/j.vaccine.2009.03.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-Gal constitutes similar to 1% of circulating IgG in humans and interacts specifically with alpha-gal epitopes. We reported previously that expression of a-gal epitopes on HIV gp120 and influenza virus vaccines increases immunogenicity by similar to 100-fold. We hypothesize that immunogenicity of any microbial vaccine can be markedly increased by linked a-gal epitopes due to in vivo formation of immune complexes with anti-Gal and the effective internalization of such immune complexes by APC, via Fc/Fc gamma R interaction. The increased transport to lymph nodes and processing of anti-Gal complexed vaccines internalized by APC, results in effective activation of vaccine specific CD4(+) and CD8(+) T cells, and high cellular and humoral immune response. This universal mechanism for anti-Gal mediated increased immunogenicity is demonstrated in alpha 1,3galactosyltransferase knockout mice with ovalbumin as a model vaccine. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3072 / 3082

页数：11

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