Finally! The Brambell receptor (FcRB) - Mediator of transmission of immunity and protection from catabolism for IgG

被引：163

作者：

Junghans, RP ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, FAC IMMUNOL, BOSTON, MA 02215 USA

来源：

IMMUNOLOGIC RESEARCH | 1997年 / 16卷 / 01期

关键词：

passive immunity; transmission; IgG catabolism; receptor recycling; FcRn; FcRp; FcRB;

D O I：

10.1007/BF02786322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

F. W. Rogers Brambell was the father of the field of transmission of immunity, which he entered 50 years before the present era. As part of his quantitative and temporal studies on transmission, he defined the first Fc receptor system for IgG, and furthermore recognized the link between transmission of passive immunity from mother to young and protection from catabolism for IgG. This article provides a historical overview of the efforts of Professor Brambell and summarizes the subsequent elaboration of the details of the physiology and molecular biology of this remarkable receptor system.

引用

页码：29 / 57

页数：29

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