Reproductive functions of the progesterone receptor

被引：59

作者：

Conneely, OM ^{[1
]}

Lydon, JP ^{[1
]}

De Mayo, F ^{[1
]}

O'Malley, BW ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA

来源：

JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION | 2000年 / 7卷 / 01期

关键词：

progesterone; progesterone receptor A; progesterone receptor B; progesterone receptor knock-out mice;

D O I：

10.1016/S1071-5576(99)00062-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Progesterone plays a central coordinate role in regulating reproductive events associated with the establishment and maintenance of pregnancy including ovulation, uterine and mammary gland development and tumorigenesis, and neurobehavioral expression associated with sexual responsiveness. The effects of progesterone are mediated by two receptor proteins (PR), termed A and B, that arise from a single gene and act as ligand-activated transcription factors to regulate the expression of reproductive target genes. Null mutation of both proteins in mice leads to pleiotropic reproductive abnormalities. This review summarizes the structure and functional properties of the PR isoforms and how functional differences between these proteins are likely to impact on the overall physiologic role of the receptor in reproductive systems. (J Soc Gynecol Investig 2000;7:S25-32) Copyright (C) 2000 by the Society for Gynecologic Investigation.

引用

页码：S25 / S32

页数：8

共 114 条

[1]

ALLAN GF, 1992, J BIOL CHEM, V267, P19513

[2] LIGAND-DEPENDENT CONFORMATIONAL-CHANGES IN THE PROGESTERONE-RECEPTOR ARE NECESSARY FOR EVENTS THAT FOLLOW DNA-BINDING [J].

ALLAN, GF ;

TSAI, SY ;

TSAI, MJ ;

OMALLEY, BW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :11750-11754

[3] PROGESTERONE-RECEPTOR REGULATION IN UTERINE CELLS - STIMULATION BY ESTROGEN, CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE, AND INSULIN-LIKE GROWTH FACTOR-I AND SUPPRESSION BY ANTIESTROGENS AND PROTEIN-KINASE INHIBITORS [J].

ARONICA, SM ;

KATZENELLENBOGEN, BS .

ENDOCRINOLOGY, 1991, 128 (04) :2045-2052

[4] ESTROGEN ACTION VIA THE CAMP SIGNALING PATHWAY - STIMULATION OF ADENYLATE-CYCLASE AND CAMP-REGULATED GENE-TRANSCRIPTION [J].

ARONICA, SM ;

KRAUS, WL ;

KATZENELLENBOGEN, BS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (18) :8517-8521

[5] STIMULATION OF ESTROGEN RECEPTOR-MEDIATED TRANSCRIPTION AND ALTERATION IN THE PHOSPHORYLATION STATE OF THE RAT UTERINE ESTROGEN-RECEPTOR BY ESTROGEN, CYCLIC ADENOSINE-MONOPHOSPHATE, AND INSULIN-LIKE GROWTH FACTOR-I [J].

ARONICA, SM ;

KATZENELLENBOGEN, BS .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (06) :743-752

[6] THE PROGESTERONE ANTAGONIST RU486 ACQUIRES AGONIST ACTIVITY UPON STIMULATION OF CAMP SIGNALING PATHWAYS [J].

BECK, CA ;

WEIGEL, NL ;

MOYER, ML ;

NORDEEN, SK ;

EDWARDS, DP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4441-4445

[7] Differential expression of progestin receptor isoforms in the hypothalamus, pituitary, and endometrium of rhesus macaques [J].

Bethea, CL ;

Widmann, AA .

ENDOCRINOLOGY, 1998, 139 (02) :677-687

[8]

BOZIC CR, 1994, J BIOL CHEM, V269, P29355

[9] PROGESTERONE-RECEPTOR MESSENGER-RIBONUCLEIC-ACID AND PROTEIN ARE OVEREXPRESSED IN HUMAN UTERINE LEIOMYOMAS [J].

BRANDON, DD ;

BETHEA, CL ;

STRAWN, EY ;

NOVY, MJ ;

BURRY, KA ;

HARRINGTON, MS ;

ERICKSON, TE ;

WARNER, C ;

KEENAN, EJ ;

CLINTON, GM .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1993, 169 (01) :78-85

[10] ALTERNATIVE TRANSLATION INITIATION SITE USAGE RESULTS IN 2 FUNCTIONALLY DISTINCT FORMS OF THE GATA-1 TRANSCRIPTION FACTOR [J].

CALLIGARIS, R ;

BOTTARDI, S ;

COGOI, S ;

APEZTEGUIA, I ;

SANTORO, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11598-11602

← 1 2 3 4 5 6 7 8 9 10 →