How many signals impinge on GLUT4 activation by insulin?

被引：42

作者：

He, Aibin

Liu, Xiaojun

Liu, Lizhong

Chang, Yongsheng

Fang, Fude ^{[1
]}

机构：

[1] Peking Union Med Coll, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100005, Peoples R China

来源：

CELLULAR SIGNALLING | 2007年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

GLUT4; actin remodeling; Rab; Rho;

D O I：

10.1016/j.cellsig.2006.05.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

GLUT4 is the main glucose transporter activated by insulin in skeletal muscle cells and adipocytes. GLUT4 storage vesicles (GSVs) traffic in endocytic and exocytic compartments. In the basal state, GLUT4 compartments are preferentially sequestered in perinuclear deposits wherein stimuli including insulin and non-insulin factors can increase GLUT4 vesicle formation, its exocytosis, and fusion to plasma membrane. In addition to well-established effectors of insulin signaling pathway, such as PKCzeta and Akt, the cytoskeletal network is implicated in GLUT4 translocation. This review will discuss the mechanisms and activation of GLUT4 trafficking and incorporating to PM from three aspects: known molecules of the insulin signaling pathway; Rho and Rab family proteins and cytoskeletal molecules. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1 / 7

页数：7

共 90 条

[61]

Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (lhosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes [J].