Ultra-high-speed volumetric tomography of human retinal blood flow

被引：104

作者：

Schmoll, Tilman ^{[1
]}

Kolbitsch, Christoph ^{[1
]}

Leitgeb, Rainer A. ^{[1
]}

机构：

[1] Med Univ Vienna, Ctr Biomed Engn & Phys, A-1090 Vienna, Austria

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 05期

关键词：

OPTICAL COHERENCE TOMOGRAPHY; DOPPLER TOMOGRAPHY; AXIAL SCANS; RESOLUTION; ANGIOGRAPHY; VESSELS;

D O I：

10.1364/OE.17.004166

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Applying novel detector development based on CMOS technology to Fourier domain optical coherence tomography we achieve depth profile rates up to 200,000 scans/sec. This speed allows for dramatic improvement for imaging small retinal details, such as photo-receptors and capillaries. We demonstrate the impact of this achievable speed to Doppler tomography and discuss advantages as well as short-comings of high speed 3D Doppler imaging of the human retina. Experimental data of 3D static D-FDOCT sets from fovea and nerve head region are shown together with first 4D imaging of retinal capillary flow. (C) 2009 Optical Society of America

引用

页码：4166 / 4176

页数：11

共 33 条

[1] In vivo volumetric imaging of vascular perfusion within human retina and choroids with optical micro-angiography [J].

An, Lin ;

Wang, Ruikang K. .

OPTICS EXPRESS, 2008, 16 (15) :11438-11452

[2] Resonant Doppler flow imaging and optical vivisection of retinal blood vessels [J].

Bachmann, Adrian H. ;

Villiger, Martin L. ;

Blatter, Cedric ;

Lasser, Theo ;

Leitgeb, Rainer A. .

OPTICS EXPRESS, 2007, 15 (02) :408-422

[3] Spectral-domain phase microscopy [J].

Choma, MA ;

Ellerbee, AK ;

Yang, CH ;

Creazzo, TL ;

Izatt, JA .

OPTICS LETTERS, 2005, 30 (10) :1162-1164

[4] Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[5] Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].

de Boer, JF ;

Cense, B ;

Park, BH ;

Pierce, MC ;

Tearney, GJ ;

Bouma, BE .

OPTICS LETTERS, 2003, 28 (21) :2067-2069

[6] The impact of ocular blood flow in glaucoma [J].

Flammer, J ;

Orgül, S ;

Costa, VP ;

Orzalesi, N ;

Krieglstein, GK ;

Serra, LM ;

Renard, JP ;

Stefánsson, E .

PROGRESS IN RETINAL AND EYE RESEARCH, 2002, 21 (04) :359-393

[7] A hemodynamic model of the pathogenesis of age-related macular degeneration [J].

Friedman, E .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1997, 124 (05) :677-682

[8] Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second [J].

Huber, R. ;

Adler, D. C. ;

Srinivasan, V. J. ;

Fujimoto, J. G. .

OPTICS LETTERS, 2007, 32 (14) :2049-2051

[9] Dual-beam Fourier domain optical Doppler tomography of zebrafish [J].

Iftimia, Nicusor V. ;

Hammer, Daniel X. ;

Ferguson, R. Daniel ;

Mujat, Mircea ;

Vu, Danthu ;

Ferrante, Anthony A. .

OPTICS EXPRESS, 2008, 16 (18) :13624-13636

[10]

*INT EL COMM, 2001, 608251 IEC EN

← 1 2 3 4 →