Eicosanoid-dependent cancer cachexia and wasting

被引：31

作者：

Ross, JA ^{[1
]}

Fearon, KCH ^{[1
]}

机构：

[1] Univ Edinburgh, Royal Infirm Edinburgh, Dept Clin & Surg Sci, Lister Res Labs, Edinburgh EH3 9YW, Midlothian, Scotland

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2002年 / 5卷 / 03期

关键词：

D O I：

10.1097/00075197-200205000-00002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The reversal of catabolic processes remains a significant challenge related, in part, to their complexity and our incomplete understanding of the mechanisms involved. The eicosanoids are key players in the inflammatory process and have been implicated in the process of cancer cachexia. They are unsaturated C20 fatty acids which can be separated into two main groups: the lipoxygenase products including leukotrienes and lipoxins, and the prostanoids including prostaglandins, prostacyclin and thromboxane. This review examines the biology of the eicosanoids and the evidence of a role for the eicosanoids in cancer cachexia and wasting. (C) 2002 Lippincott Williams Wilkins.

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页码：241 / 248

页数：8

相关论文

共 56 条

[41] Why there are two cyclooxygenase isozymes [J].

Smith, WL ;

Langenbach, R .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (12) :1491-1495

[42] Cyclooxygenases: Structural, cellular, and molecular biology [J].

Smith, WL ;

DeWitt, DL ;

Garavito, RM .

ANNUAL REVIEW OF BIOCHEMISTRY, 2000, 69 :145-182

[43] EFFECTS OF SYSTEMIC INHIBITION OF PROSTAGLANDIN PRODUCTION ON PROTEIN-METABOLISM IN TUMOR-BEARING RATS [J].

STRELKOV, AB ;

FIELDS, ALA ;

BARACOS, VE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (02) :C261-C269

[44] HUMORAL MEDIATION FOR CACHEXIA IN TUMOR-BEARING RATS [J].

TESSITORE, L ;

COSTELLI, P ;

BACCINO, FM .

BRITISH JOURNAL OF CANCER, 1993, 67 (01) :15-23

[45] Signalling pathways regulating protein turnover in skeletal muscle [J].

Thompson, MG ;

Palmer, RM .

CELLULAR SIGNALLING, 1998, 10 (01) :1-11

[46] Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes [J].

Tilley, SL ;

Coffman, TM ;

Koller, BH .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (01) :15-23

[47]

Tisdale M J, 1998, Curr Opin Clin Nutr Metab Care, V1, P253, DOI 10.1097/00075197-199805000-00003

[48] Metabolic abnormalities in cachexia and anorexia [J].

Tisdale, MJ .

NUTRITION, 2000, 16 (10) :1013-1014

[49]

Watchorn TM, 2001, FASEB J, V15, P562

[50] IBUPROFEN REDUCES ENERGY-EXPENDITURE AND ACUTE-PHASE PROTEIN-PRODUCTION COMPARED WITH PLACEBO IN PANCREATIC-CANCER PATIENTS [J].

WIGMORE, SJ ;

FALCONER, JS ;

PLESTER, CE ;

ROSS, JA ;

MAINGAY, JP ;

CARTER, DC ;

FEARON, KCH .

BRITISH JOURNAL OF CANCER, 1995, 72 (01) :185-188

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