Low perforin and elevated SHIP-1 expression is associated with functional anergy of natural killer cells in chronic HIV-1 infection

被引：29

作者：

Alter, Galit

Suscovich, Todd J.

Kleyman, Marianna

Teigen, Nickolas

Streeck, Hendrik

Zaman, M. Tauheed

Meier, Angela

Altfeld, Marcus ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Div Aids, Boston, MA 02114 USA

来源：

AIDS | 2006年 / 20卷 / 11期

关键词：

D O I：

10.1097/01.aids.0000237371.31315.48

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are critical for the first-line defense in infection. Treated viremic HIV-1 infection is associated with the expansion of an anergic subset of CD3-CD56-CD16+ NK cells unable to respond to stimulation with MHC-devoid target cells or with mitogens. These CD3-CD56-CD16+ NK cells expressed SHIP-1 and had significantly reduced perforin levels. This observation suggests a mechanism for the reduced functional activity of CD3-CD56-CD16+ NK cells in chronic HIV-1 infection.

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收藏

页码：1549 / 1551

页数：3

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