Alzheimer's disease - The tangled tale of tau

被引：71

作者：

Mandelkow, E ^{[1
]}

机构：

[1] Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

来源：

NATURE | 1999年 / 402卷 / 6762期

关键词：

D O I：

10.1038/45095

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alzheimer's disease is characterized by the accumulation of aggregated tau protein. These aggregates are thought to form because hyperphosphorylation of tau causes it to dissociate from the microtubules to which it normally binds, and the tau molecules can then bind to one another. The cyclin-dependent kinase-5 (Cdk5) is suspected to be the kinase that hyperphosphorylates tau, and a new study reveals how Cdk5 might do this.

引用

页码：588 / 589

页数：2

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