Characterization and chromosome location of the mouse link protein gene (Crtl1)

被引：6

作者：

Deák, F

Mátés, L

Krysan, K

Liu, Z

Szabó, PE

Mann, JR

Beier, DR

Kiss, I

机构：

[1] Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[3] City Hope Natl Med Ctr, Beckman Res Inst, Div Biol, Duarte, CA 91010 USA

来源：

CYTOGENETICS AND CELL GENETICS | 1999年 / 87卷 / 1-2期

关键词：

D O I：

10.1159/000015395

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Link protein (LP) plays an essential role in endochondral bone formation by stabilizing the supramolecular assemblies of aggrecan and hyaluronan. We have isolated and characterized the mouse link protein gene (Crtl1). It is longer than 40 kb and transcribed from two alternative promoters, leading to heterogenous mRNAs between 5.3 and 1.3 kb in size. Apart from the coding sequence, the 5' flanking region is also highly conserved in mammals. Immunostaining revealed high levels of LP expression in the cartilaginous primordia of skeletal elements and low levels in other tissues. Using single-strand conformation polymorphism analysis, Crtl1 was assigned to mouse chromosome 13, tightly linked to Dhfr. Copyright (C) 1999 S. Karger AG, Basel.

引用

页码：75 / 79

页数：5

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