Iron homeostasis in the brain:: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse

被引:48
作者
Galy, Bruno
Hoelter, Sabine M.
Klopstock, Thomas
Ferring, Dunja
Becker, Lore
Kaden, Sylvia
Wurst, Wolfgang
Groene, Hermann-Josef
Hentze, Matthias W.
机构
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
[2] GSF, Natl Res Ctr Environm & Hlth, Inst Dev Genet, D-85764 Neuherberg, Germany
[3] GSF, Natl Res Ctr Environm & Hlth, Inst Expt Genet, D-85764 Neuherberg, Germany
[4] Univ Munich, Dept Neurol, D-81377 Munich, Germany
[5] Max Planck Inst Psychiat, D-80804 Munich, Germany
[6] Deutsch Krebsforschungszentrum, Abt Zellulare & Mol Pathol, D-69120 Heidelberg, Germany
关键词
D O I
10.1038/ng0906-967
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:967 / 969
页数:4
相关论文
共 9 条
[1]   Genetic and behavioral differences among five inbred mouse strains commonly used in the production of transgenic and knockout mice [J].
Bothe, GWM ;
Bolivar, VJ ;
Vedder, MJ ;
Geistfeld, JG .
GENES BRAIN AND BEHAVIOR, 2004, 3 (03) :149-157
[2]   Lipofuscin: Mechanisms of age-related accumulation and influence on cell function [J].
Brunk, UT ;
Terman, A .
FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (05) :611-619
[3]   Generation of conditional allele of the murine iron regulatory protein (IRP)-1 and -2 genes [J].
Galy, B ;
Ferring, D ;
Hentze, MW .
GENESIS, 2005, 43 (04) :181-188
[4]   Balancing acts: Molecular control of mammalian iron metabolism [J].
Hentze, MW ;
Muckenthaler, MU ;
Andrews, NC .
CELL, 2004, 117 (03) :285-297
[5]   Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice [J].
LaVaute, T ;
Smith, S ;
Cooperman, S ;
Iwai, K ;
Land, W ;
Meyron-Holtz, E ;
Drake, SK ;
Miller, G ;
Abu-Asab, M ;
Tsokos, M ;
Switzer, R ;
Grinberg, A ;
Love, P ;
Tresser, N ;
Rouault, TA .
NATURE GENETICS, 2001, 27 (02) :209-214
[6]   The modified hole board as a differential screen for behavior in rodents [J].
Ohl, F ;
Holsboer, F ;
Landgraf, R .
BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS, 2001, 33 (03) :392-397
[7]   Know your neighbors: Three phenotypes in null mutants of the myogenic bHLH gene MRF4 [J].
Olson, EN ;
Arnold, HH ;
Rigby, PWJ ;
Wold, BJ .
CELL, 1996, 85 (01) :1-4
[8]   Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies [J].
Smith, SR ;
Cooperman, S ;
Lavaute, T ;
Tresser, N ;
Ghosh, M ;
Meyron-Holtz, E ;
Land, W ;
Ollivierre, H ;
Jortner, B ;
Switzer, R ;
Messing, A ;
Rouault, TA .
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS, 2004, 1012 :65-83
[9]   Different data from different labs: Lessons from studies of gene-environment interaction [J].
Wahlsten, D ;
Metten, P ;
Phillips, TJ ;
Boehm, SL ;
Burkhart-Kasch, S ;
Dorow, J ;
Doerksen, S ;
Downing, C ;
Fogarty, J ;
Rodd-Henricks, K ;
Hen, R ;
McKinnon, CS ;
Merrill, CM ;
Nolte, C ;
Schalomon, M ;
Schlumbohm, JP ;
Sibert, JR ;
Wenger, CD ;
Dudek, BC ;
Crabbe, JC .
JOURNAL OF NEUROBIOLOGY, 2003, 54 (01) :283-311