Cardio-respiratory coupling indicates suppression of vagal activity in acute schizophrenia

被引：48

作者：

Peupelmann, Jeannine ^{[1
]}

Boettger, Michael Karl ^{[2
]}

Ruhland, Carmen ^{[1
]}

Berger, Sandy ^{[1
]}

Ramachandraiah, Chaitra T. ^{[3
]}

Yeragani, Vikram K. ^{[4
,5
]}

Baer, Karl-Juergen ^{[1
,6
]}

机构：

[1] Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany

[2] Univ Hosp, Inst Physiol, Jena, Germany

[3] Rajiv Gandhi Univ Hlth Sci, Bangalore, Karnataka, India

[4] Univ Alberta, Dept Psychiat, Edmonton, AB, Canada

[5] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA

[6] Ruhr Univ Bochum, Dept Psychiat Psychotherapy & Psychosomat Med, D-44791 Bochum, Germany

来源：

SCHIZOPHRENIA RESEARCH | 2009年 / 112卷 / 1-3期

关键词：

Autonomic function; Brain stem; Breathing rate; Respiratory sinus arrhythmia; Schizophrenia; Cardiac mortality; Psychosis; Vagal tone; HEART-RATE; RESPIRATORY RHYTHM; IRREGULARITY; ACETYLCHOLINE; NEURONS; PERTURBATIONS; VARIABILITY; MODULATION; SYMPTOMS; AMYGDALA;

D O I：

10.1016/j.schres.2009.03.042

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Altered amygdala activity in patients with schizophrenia can influence respiratory patterns and consequently cardiovascular parameters. Hence, we examined respiration and heart rate time series complexity as well as coupling of both signals. Electrocardiograms and respiratory signals were obtained from 25 unmedicated patients with schizophrenia and controls. Approximate entropy (ApEn) was calculated for heart and respiratory rates as well as cross-ApEn reflecting coupling of both signals. Coupling was decreased indicating diminished vagal modulation at the brain stem level. Regularity of breathing correlated with disease severity. These data might reflect a lack of inhibitory control over brainstem centers in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：153 / 157

页数：5

共 34 条

[1] CORRELATIONAL STUDIES OF THE SCALE FOR THE ASSESSMENT OF NEGATIVE SYMPTOMS AND THE SCALE FOR THE ASSESSMENT OF POSITIVE SYMPTOMS - AN OVERVIEW AND UPDATE [J].

ANDREASEN, NC ;

ARNDT, S ;

MILLER, D ;

FLAUM, M ;

NOPOULOS, P .

PSYCHOPATHOLOGY, 1995, 28 (01) :7-17

[2] The interaction between pupil function and cardiovascular regulation in patients with acute schizophrenia [J].

Baer, Karl-Juergen ;

Boettger, Michael Karl ;

Schulz, Steffen ;

Harzendorf, Christina ;

Agelink, Marcus Willy ;

Yeragani, Vikram K. ;

Chokka, Prtap ;

Voss, Andreas .

CLINICAL NEUROPHYSIOLOGY, 2008, 119 (10) :2209-2213

[3] Acute psychosis leads to increased QT variability in patients suffering from. schizophrenia [J].

Baer, Karl-Juergen ;

Koschke, Mandy ;

Boettger, Michael Karl ;

Berger, Sandy ;

Kabisch, Alexander ;

Sauer, Heinrich ;

Voss, Andreas ;

Yeragani, Vikram K. .

SCHIZOPHRENIA RESEARCH, 2007, 95 (1-3) :115-123

[4] Non-linear complexity measures of heart rate variability in acute schizophrenia [J].

Baer, Karl-Juergen ;

Boettger, Michael Karl ;

Koschke, Mandy ;

Schulz, Steffen ;

Chokka, Pratap ;

Yeragani, Vikrarn K. ;

Voss, Andreas .

CLINICAL NEUROPHYSIOLOGY, 2007, 118 (09) :2009-2015

[5] Decreased baroreflex sensitivity in acute schizophrenia [J].

Bar, Karl-Jurgen ;

Boettger, Michael Karl ;

Berger, Sandy ;

Baier, Vico ;

Sauer, Heinrich ;

Yeragani, Vikram K. ;

Voss, Andreas .

JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (03) :1051-1056

[6] Loss of efferent vagal activity in acute schizophrenia [J].

Bär, KJ ;

Letzsch, A ;

Jochum, T ;

Wagner, G ;

Greiner, W ;

Sauer, H .

JOURNAL OF PSYCHIATRIC RESEARCH, 2005, 39 (05) :519-527

[7] Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia [J].

Boettger, Silke ;

Hoyer, Dirk ;

Falkenhahn, Katrin ;

Kaatz, Martin ;

Yeragani, Vikram K. ;

Baer, Karl-Juergen .

CLINICAL NEUROPHYSIOLOGY, 2006, 117 (12) :2715-2722

[8] ACETYLCHOLINE AND CENTRAL RESPIRATORY CONTROL - PERTURBATIONS OF ACETYLCHOLINE SYNTHESIS IN THE ISOLATED BRAIN-STEM OF THE NEONATAL RAT [J].

BURTON, MD ;

NOURI, M ;

KAZEMI, H .

BRAIN RESEARCH, 1995, 670 (01) :39-47

[9] VENTILATORY OUTPUT AND ACETYLCHOLINE - PERTURBATIONS IN RELEASE AND MUSCARINIC RECEPTOR ACTIVATION [J].

BURTON, MD ;

NOURI, K ;

BAICHOO, S ;

SAMUELSTOYLOY, N ;

KAZEMI, H .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 77 (05) :2275-2284

[10] The central respiratory effects of acetylcholine vary with CSF pH [J].

Burton, MD ;

Johnson, DC ;

Kazemi, H .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1997, 62 (1-2) :27-32

← 1 2 3 4 →