VENTILATORY OUTPUT AND ACETYLCHOLINE - PERTURBATIONS IN RELEASE AND MUSCARINIC RECEPTOR ACTIVATION

被引:43
作者
BURTON, MD [1 ]
NOURI, K [1 ]
BAICHOO, S [1 ]
SAMUELSTOYLOY, N [1 ]
KAZEMI, H [1 ]
机构
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
关键词
CONTROL OF BREATHING; ISOLATED BRAIN STEM; CETIEDIL; VESAMICOL; 4-AMINOPYRIDINE; MUSCARINIC BLOCKERS; TETRAETHYLAMMONIUM CHLORIDE;
D O I
10.1152/jappl.1994.77.5.2275
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Cholinergic transmission may be part of the normal neurochemical processes that support spontaneous ventilation. If this is true, perturbations in acetylcholine (ACh) turnover should alter ventilatory output in a predictable manner. With the use of the isolated perfused brain stem-spinal axis from the neonatal rat, the effects of modifiers of ACh release and blockers of muscarinic receptors on spontaneous C-4 (phrenic) output were determined. Vesamicol and cetiedil, inhibitors of ACh release, caused depression and cessation of the C-4 output in a dose-dependent manner when added to the perfusate. Muscarinic blockers, particularly M(1) and M(3) blockers, caused a similar depression. 4-Aminopyridine and tetraethylammonium chloride, facilitators of ACh release, caused stimulation of C-4 (phrenic) output. The depressive effects of the blockers and inhibitors were reversible with facilitation of ACh release except in the case of cetiedil. These findings are consistent with the view that the synaptic turnover of endogenous ACh is an important part of the normal neurochemical process that supports and modulates ventilation.
引用
收藏
页码:2275 / 2284
页数:10
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