The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats

被引：22

作者：

Li, ZQ

Yamamoto, Y

Morimoto, T

Ono, J

Okada, S

Yamatodani, A

机构：

[1] Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, Osaka 5650871, Japan

[2] Osaka Univ, Fac Med, Dept Pediat, Osaka 5650871, Japan

来源：

NEUROSCIENCE LETTERS | 2000年 / 282卷 / 1-2期

关键词：

pentylenetetrazole; kindling; glutamate; microdialysis; seizure; epilepsy;

D O I：

10.1016/S0304-3940(00)00838-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was observed in the non-kindled rats when the same grade seizure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：117 / 119

页数：3

共 15 条

[11] Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats [J].