Expression Patterns of Angiopoietin-1,-2, and Tie-2 Receptor in Ulcerative Colitis Support Involvement of the Angiopoietin/Tie Pathway in the Progression of Ulcerative Colitis

被引：11

作者：

Yoshizaki, Ayumi ^{[1
]}

Nakayama, Toshiyuki ^{[1
]}

Naito, Shinji ^{[2
]}

Sekine, Ichiro ^{[1
]}

机构：

[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Tumor & Diagnost Pathol, Nagasaki 8528523, Japan

[2] Natl Ureshino Med Ctr, Div Pathol, Res Lab, Saga, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 10期

关键词：

Ulcerative colitis; Crypt abscess; Immunohistochemistry; Angiopoietin; Tie; INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; QUALITY-OF-LIFE; TYROSINE KINASE; 5-AMINOSALICYLIC ACID; ENDOTHELIAL-CELLS; ADHESION MOLECULES; KAPPA-B; ANGIOGENESIS; THERAPY;

D O I：

10.1007/s10620-008-0593-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The active stage of ulcerative colitis (UC) involves transmigration of polymorphonuclear (PMN) cells to colonic epithelia. The angiopoietin (Ang) pathway plays a role as the regulator of PMN transmigration. To clarify the role of the Ang/Tie pathway in the activation of UC, especially in cypt abscess formation, 67 tissue samples were obtained from patients with UC and ten controls without UC for immunohistochemical analysis for the expression of Ang-1, -2, or Tie-2. The epithelia of crypt abscess was strongly positive for Ang-1 and -2 for all 57 samples derived from patients with active UC, though the colorectal epithelium without crypt abscess showed minimal expression of Ang-1, -2, and Tie-2. Numerous transepithelial migrating PMN cells in crypt abscesses also expressed Tie-2. The specimens of UC patients in remission showed significantly less immunoreactivity for Ang-1, -2, or Tie-2. These findings suggest that the Ang/Tie pathway may play a role in the progression of UC.

引用

页码：2094 / 2099

页数：6

共 44 条

[1]

Biologic therapy in the management of extraintestinal manifestations of inflammatory bowel disease [J].