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H-NS, the genome sentinel

被引：264
作者：
Dorman, Charles J. [1 ]
机构：
[1] Univ Dublin Trinity Coll, Dept Microbiol, Dublin 2, Ireland
来源：
NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1038/nrmicro1598
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?
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页码：157 / 161
页数：5
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