H-NS, the genome sentinel

被引:264
作者
Dorman, Charles J. [1 ]
机构
[1] Univ Dublin Trinity Coll, Dept Microbiol, Dublin 2, Ireland
基金
英国惠康基金;
关键词
D O I
10.1038/nrmicro1598
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Two recent reports have indicated that the H-NS protein in Salmonella enterica serovar Typhimurium has a key role in selectively silencing the transcription of large numbers of horizontally acquired AT-rich genes, including those that make up its major pathogenicity islands. Broadly similar conclusions have emerged from a study of H-NS binding to DNA in Escherichia coli. How do these findings affect our view of H-NS and its ability to influence bacterial evolution?
引用
收藏
页码:157 / 161
页数:5
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