Optimizing Hemodynamics in Heart Failure Patients by Systematic Screening of Left Ventricular Pacing Sites The Lateral Left Ventricular Wall and the Coronary Sinus Are Rarely the Best Sites

被引：197

作者：

Derval, Nicolas ^{[1
]}

Steendijk, Paul ^{[2
]}

Gula, Lorne J. ^{[3
]}

Deplagne, Antoine ^{[1
]}

Laborderie, Julien ^{[1
]}

Sacher, Frederic ^{[1
]}

Knecht, Sebastien ^{[1
]}

Wright, Matthew ^{[1
]}

Nault, Isabelle ^{[1
]}

Ploux, Sylvain ^{[1
]}

Ritter, Philippe ^{[1
]}

Bordachar, Pierre ^{[1
]}

Lafitte, Stephane ^{[1
]}

Reant, Patricia ^{[1
]}

Klein, George J. ^{[3
]}

Narayan, Sanjiv M. ^{[4
,5
]}

Garrigue, Stephane ^{[1
]}

Hocini, Meleze ^{[1
]}

Haissaguerre, Michel ^{[1
]}

Clementy, Jacques ^{[1
]}

Jais, Pierre ^{[1
]}

机构：

[1] Univ Bordeaux 2, CHU Bordeaux, Hop Cardiol Haut Leveque, F-33600 Pessac, France

[2] Leiden Univ, Med Ctr, Leiden, Netherlands

[3] Univ Western Ontario, Arrhythmia Dept, London, ON, Canada

[4] Univ Calif San Diego, San Diego, CA 92103 USA

[5] Vet Affairs Med Ctr, San Diego, CA 92161 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2010年 / 55卷 / 06期

关键词：

heart failure; resynchronization; pacing; hemodynamic; CARDIAC-RESYNCHRONIZATION THERAPY; BUNDLE-BRANCH-BLOCK; PRESSURE-VOLUME LOOPS; CONDUCTION DELAY; DIASTOLIC FUNCTION; STIMULATION SITE; ACTIVATION; CARDIOMYOPATHY; DYSSYNCHRONY; MORTALITY;

D O I：

10.1016/j.jacc.2009.08.045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives We sought to evaluate the impact of the left ventricular (LV) pacing site on hemodynamic response to cardiac resynchronization therapy (CRT). Background CRT reduces morbidity and mortality in heart failure patients. However, 20% to 40% of eligible patients may not fully benefit from CRT device implantation. We hypothesized that selecting the optimal LV pacing site could be critical in this issue. Methods Thirty-five patients with nonischemic dilated cardiomyopathy referred for CRT device implantation were studied. Intraventricular dyssynchrony and latest activated LV wall were defined by tissue Doppler imaging analysis before the study. Eleven predetermined LV pacing sites were systematically assessed in random order: basal and mid-cavity (septal, anterior, lateral, inferior), apex, coronary sinus (CS), and the endocardial site facing the CS pacing site. For each patient, +dP/dT(max), -dP/dT(min), pulse pressure, and end-systolic pressure during baseline (AAI) and DDD LV pacing were compared. Two atrioventricular delays were tested. Results Major interindividual and intraindividual variations of hemodynamic response depending on the LV pacing site were observed. Compared with baseline, LV DDD pacing at the best LV position significantly improved +dP/dT(max) (+31 +/- 26%, p < 0.001) and was superior to pacing the CS (+15 +/- 23%, p < 0.001), the lateral LV wall (+18 +/- 22%, p < 0.001), or the latest activated LV wall (+11 +/- 17%, p < 0.001). Conclusions The pacing site is a primary determinant of the hemodynamic response to LV pacing in patients with nonischemic dilated cardiomyopathy. Pacing at the best LV site is associated acutely with fewer nonresponders and twice the improvement in +dP/dT(max) observed with CS pacing. (J Am Coll Cardiol 2010; 55: 566-75) (c) 2010 by the American College of Cardiology Foundation

引用

页码：566 / 575

页数：10

共 32 条

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