Searching for MIND: MicroRNAs in Neurodegenerative Diseases

被引：35

作者：

Barbato, Christian ^{[1
,2
]}

Ruberti, Francesca ^{[2
]}

Cogoni, Carlo ^{[1
,3
]}

机构：

[1] Fdn EBRI Rita Levi Montalcini, EBRI, I-00143 Rome, Italy

[2] CNR, INMM, I-00143 Rome, Italy

[3] Univ Roma La Sapienza, Dipartimento Biotecnol Cellulari & Ematol, Sez Genet Mol, I-00161 Rome, Italy

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2009年

关键词：

ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; PARKINSON-DISEASE; BINDING-SITE; PROTEIN; EXPRESSION; BRAIN; GENE; BETA; DEGENERATION;

D O I：

10.1155/2009/871313

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In few years our understanding of microRNA (miRNA) biogenesis, molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has been expanded. Interestingly, numerous miRNAs are expressed in a spatially and temporally controlled manner in the nervous system, suggesting that their posttrascriptional regulation may be particularly relevant in neural development and function. MiRNA studies in neurobiology showed their involvement in synaptic plasticity and brain diseases. In this review, correlations between miRNA-mediated gene silencing and Alzheimer's, Parkinson's, and other neurodegenerative diseases will be discussed. Molecular and cellular neurobiological studies of the miRNAs in neurodegeneration represent the exploration of a new Frontier of miRNAs biology and the potential development of new diagnostic tests and genetic therapies for neurodegenerative diseases. Copyright (C) 2009 Christian Barbato et al.

引用

页数：8

共 36 条

[1] The prion's elusive reason for being [J].

Aguzzi, Adriano ;

Baumann, Frank ;

Bremer, Jullane .

ANNUAL REVIEW OF NEUROSCIENCE, 2008, 31 :439-477

[2] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[3] Thinking about RNA? MicroRNAs in the brain [J].

Barbato, Christian ;

Giorgi, Corinna ;

Catalanotto, Caterina ;

Cogoni, Carlo .

MAMMALIAN GENOME, 2008, 19 (7-8) :541-551

[4] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[5] Diversity of microRNAs in human and chimpanzee brain [J].

Berezikov, Eugene ;

Thuemmler, Fritz ;

van Laake, Linda W. ;

Kondova, Ivanela ;

Bontrop, Ronald ;

Cuppen, Edwin ;

Plasterk, Ronald H. A. .

NATURE GENETICS, 2006, 38 (12) :1375-1377

[6] MicroRNA pathways modulate polyglutamine-induced neurodegeneration [J].

Bilen, Julide ;

Liu, Nan ;

Burnett, Barrington G. ;

Pittman, Randall N. ;

Bonini, Nancy M. .

MOLECULAR CELL, 2006, 24 (01) :157-163

[7] MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1 [J].

Boissonneault, Vincent ;

Plante, Isabelle ;

Rivest, Serge ;

Provost, Patrick .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (04) :1971-1981

[8] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[9] Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration [J].

Cairns, Nigel J. ;

Bigio, Eileen H. ;

Mackenzie, Ian R. A. ;

Neumann, Manuela ;

Lee, Virginia M. -Y. ;

Hatanpaa, Kimmo J. ;

White, Charles L., III ;

Schneider, Julie A. ;

Grinberg, Lea Tenenholz ;

Halliday, Glenda ;

Duyckaerts, Charles ;

Lowe, James S. ;

Holm, Ida E. ;

Tolnay, Markus ;

Okamoto, Koichi ;

Yokoo, Hideaki ;

Murayama, Shigeo ;

Woulfe, John ;

Munoz, David G. ;

Dickson, Dennis W. ;

Ince, Paul G. ;

Trojanowski, John Q. ;

Mann, David M. A. .

ACTA NEUROPATHOLOGICA, 2007, 114 (01) :5-22

[10] Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways [J].

Cogswell, John P. ;

Ward, James ;

Taylor, Ian A. ;

Waters, Michelle ;

Shi, Yunling ;

Cannon, Brian ;

Kelnar, Kevin ;

Kemppainen, Jon ;

Brown, David ;

Chen, Caifu ;

Prinjha, Rab K. ;

Richardson, Jill C. ;

Saunders, Ann M. ;

Roses, Allen D. ;

Richards, Cynthia A. .

JOURNAL OF ALZHEIMERS DISEASE, 2008, 14 (01) :27-41

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