Coronary Heart Disease in Postmenopausal Women with Type II Diabetes Mellitus and the Impact of Estrogen Replacement Therapy: A Narrative Review

被引：20

作者：

Boukhris, Marouane ^{[1
,2
]}

Tomasello, Salvatore Davide ^{[1
,2
]}

Marza, Francesco ^{[1
,2
]}

Bregante, Sonia ^{[3
]}

Pluchinotta, Francesca Romana ^{[3
]}

Galassi, Alfredo Ruggero ^{[1
,2
]}

机构：

[1] Univ Catania, Cannizzaro Hosp, Dept Med Sci & Pediat, Catheterizat Lab, I-95126 Catania, Italy

[2] Univ Catania, Cannizzaro Hosp, Cardiovasc Intervent Unit, I-95126 Catania, Italy

[3] IRCCS Policlin S Donato, I-20097 Milan, Italy

来源：

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2014年 / 2014卷

关键词：

AMBULATORY BLOOD-PRESSURE; IMPAIRED FASTING GLUCOSE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; PLUS PROGESTIN; GLYCEMIC CONTROL; ARTERY-DISEASE; NITRIC-OXIDE; RISK-FACTORS;

D O I：

10.1155/2014/413920

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Coronary heart disease is the main cause of death in postmenopausal women (PMW); moreover its mortality exceeds those for breast cancer in women at all ages. Type II diabetes mellitus is a major cardiovascular risk factor and there is some evidence that the risk conferred by diabetes is greater in women than in men. It was established that the deficiency of endogenous estrogens promotes the atherosclerosis process. However, the impact of estrogen replacement therapy (ERT) on cardiovascular prevention remains controversial. Some authors strongly recommend it, whereas others revealed a concerning trend toward harm. This review tries to underlines the different components of cardiovascular risk in diabetic PMW and to define the place of ERT.

引用

页数：8

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