Biocatalytic and biomimetic aminolysis reactions: useful tools for selective transformations on polyfunctional substrates

被引:50
作者
Alfonso, I [1 ]
Gotor, V [1 ]
机构
[1] Univ Oviedo, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain
关键词
D O I
10.1039/b307785n
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Aminolysis is a deeply studied reaction, but the development of new catalysts for this process is still an emerging area of organic and bioorganic chemistry. Two different approaches are reviewed in this article: the biornimetic de novo designed synthetic catalysts and the use of natural enzymes. Brief mechanistic considerations are discussed. Some important aspects like chemo-, regio- and stereoselectivity towards the substrates are highlighted on selected examples with synthetic applications.
引用
收藏
页码:201 / 209
页数:9
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