Hyaluronic Acid-Quantum Dot Conjugates for In Vivo Lymphatic Vessel Imaging

被引：140

作者：

Bhang, Suk Ho ^{[2
]}

Won, Nayoun ^{[1
]}

Lee, Tae-Jin ^{[2
]}

Jin, Ho ^{[1
]}

Nam, Jutaek ^{[1
]}

Park, Joonhyuck ^{[1
]}

Chung, Hyokyun ^{[1
]}

Park, Hyun-Seo ^{[3
,4
]}

Sung, Yung-Eun ^{[3
,4
]}

Hahn, Sei Kwang ^{[5
]}

Kim, Byung-Soo ^{[2
]}

Kim, Sungjee ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Kyungbuk 790784, South Korea

[2] Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea

[3] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[4] Seoul Natl Univ, Res Ctr Energy Convers & Storage, Seoul 151744, South Korea

[5] Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Kyungbuk 790784, South Korea

来源：

ACS NANO | 2009年 / 3卷 / 06期

关键词：

hyaluronic acid; fluorescence; lymphangiogenesis; quantum dots; surface modification; SEMICONDUCTOR NANOCRYSTALS; INTRACELLULAR DELIVERY; LIVE CELLS; CYTOTOXICITY; METASTASIS; LYMPHANGIOGENESIS; NANOPARTICLES; GLYCOPROTEIN; VASCULATURE; RECEPTOR;

D O I：

10.1021/nn900138d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and novel electrostatic coupling method is reported, which provides a hyaluronic acid-quantum dot conjugate (HA-QD) that is colloidally stable and size-tunable from 50 to 120 nm. The HA-QDs show cancer targeting efficiency, which suggests diagnostic and imaging applications. The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels in vitro and in vivo. Using the HA-QDs in a small animal model, lymphatic vessels are visualized real-time in vivo for days. Comprehensive cytotoxicity evaluations are made for the conjugates and the unconjugated counterpart. The HA-QDs showcase the potentials toward cancer imaging and real-time visualization of changes in lymphatic vessels such as lymphangiogenesis.

引用

页码：1389 / 1398

页数：10

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