Genetic susceptibility to malaria getting complex

被引：69

作者：

Kwiatkowski, D ^{[1
]}

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX2 7BN, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(00)00087-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The evolution of sickle cell disease illustrates the powerful selective pressure of malaria in Africa, and candidate gene association studies have identified more than ten putative susceptibility determinants involving erythrocytes or the immune system. Efforts at present are aimed at understanding the functional basis of known associations, and at developing both linkage- and association-based approaches of genome-wide screening for novel susceptibility factors.

引用

页码：320 / 324

页数：5

共 47 条

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