ACETYLATION OF MITOCHONDRIAL PROTEINS

被引：51

作者：

Hirschey, Matthew D. ^{[1
]}

Shimazu, Tadahiro ^{[1
]}

Huang, Jing-Yi ^{[1
]}

Verdin, Eric ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94143 USA

来源：

METHODS IN ENZYMOLOGY, VOL 457: MITOCHONDRIAL FUNCTION, PARTB MITOCHONDRIAL PROTEIN KINASES, PROTEIN PHOSPHATASES AND MITOCHONDRIAL DISEASES | 2009年 / 457卷

关键词：

LYSINE ACETYLATION; SIRTUINS; DEACETYLASE; SIRT3;

D O I：

10.1016/S0076-6879(09)05008-3

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Sirtuins (SIRT1-SIRT7) are a family of NAD(+)-dependent protein deacetylases that regulate cell survival, metabolism, and longevity. SIRT3 is localized to the mitochondria where it deacetylates several key metabolic enzymes: acetylcoenzyme A synthetase, glutamate dehydrogenase, and subunits of complex I and thereby regulates their enzymatic activity. SIRT3 is therefore emerging as a metabolic sensor that responds to change in the energy status of the cell via NAD+ and that modulates the activity of key metabolic enzymes via protein deacetylation. Here we review experimental approaches that can be used in vitro and in vivo to study the role of acetylation in mitochondrial cell biology.

引用

页码：137 / 147

页数：11

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