Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation

被引:66
作者
Takano, Masamichi [1 ]
Ohba, Takayoshi [1 ]
Inami, Shigenobu [1 ]
Seimiya, Koji [1 ]
Sakai, Shunta [1 ]
Mizuno, Kyoichi [1 ]
机构
[1] Chiba Hokusoh Hosp, Nippon Med Sch, Dept Internal Med, Chiba 2701694, Japan
关键词
stent; neointimal hyperplasia; thrombus;
D O I
10.1093/eurheartj/ehl181
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims The neointimal coverage and intracoronary thrombi within stented segments at 6 months after implantation between sirolimus-eluting stents (SESs) and bare metal stents (BMSs) were compared by direct visualization using angioscopy. Methods and results Forty-six patients (36 stable angina and 10 acute coronary syndrome) were treated with 33 SESs and 33 BMSs. Immediately after and 6 months after stenting, each of the stented segments, edge body, and overlapping segment were observed by angioscopy and the grade of neointimal coverage over the stents was classified as 0: absent neointima, 1: visible struts through thin neointima, or 2: invisible struts. The existence of thrombi was also evaluated. The average grade of the neointimal coverage at 6 months follow-up was lower in the SES than that in the BMS (edge: 1.4 +/- 0.7 vs. 1.9 +/- 0.2, body: 1.0 +/- 0.5 vs. 1.8 +/- 0.5, overlapping segment: 0.6 +/- 0.7 vs. 1.8 +/- 0.5; P < 0.0001, P < 0.0001, P=0.0069, respectively). The frequency of persistence of thrombus was significantly higher in the SESs than that in the BMSs (86 vs. 29%, respectively; P=0.031). Conclusion The present study suggested a delayed neointimal stent coverage and slower thrombus disappearance process in the SESs in comparison to the BMSs.
引用
收藏
页码:2189 / 2195
页数:7
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