Biocatalysis for industrial production of fine chemicals

被引：180

作者：

Schulze, B

Wubbolts, MG

机构：

[1] DSM Res BV, NL-6160 MD Geleen, Netherlands

[2] DSM Biotech GmbH, D-52428 Julich, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(99)00042-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chiral intermediates constitute a significant part of the fine chemicals market, which is strongly influenced by trends in the pharmaceutical industries, where similar to 70% of pharmaceuticals are expected to be enantiomerically pure in the next century as compared to 25% today. The main technologies by which enantiomerically pure ingredients are obtained today are (dynamic) resolutions of racemic mixtures. Asymmetric syntheses are being developed, but their applications in industry are still under represented. Biotechnological methods, resolutions as well as asymmetric syntheses, are becoming increasingly important in the industrial production of fine chemicals.

引用

收藏

页码：609 / 615

页数：7

相关论文

共 63 条

[21]

HANZAWA S, 1999, ENCY BIOPROCESS TECH, P2527

[22] High-level intracellular expression of hydroxynitrile lyase from the tropical rubber tree Hevea brasiliensis in microbial hosts [J].

Hasslacher, M ;

Schall, M ;

Hayn, M ;

Bona, R ;

Rumbold, K ;

Luckl, J ;

Griengl, H ;

Kohlwein, SD ;

Schwab, H .

PROTEIN EXPRESSION AND PURIFICATION, 1997, 11 (01) :61-71

[23]

HULSHOF LA, 1989, Patent No. 0343714

[24] Relationship between an increase in thermostability and amino acid substitutions in N-carbamyl-D-amino acid amidohydrolase [J].

Ikenaka, Y ;

Nanba, H ;

Yajima, K ;

Yamada, Y ;

Takano, M ;

Takahashi, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1998, 62 (09) :1672-1675

[25] Enzymatic synthesis of silicon-containing dipeptides with 3-trimethylsilylalanine [J].

Ishikawa, H ;

Yamanaka, H ;

Kawamoto, T ;

Tanaka, A .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1999, 51 (04) :470-473

[26] Microbial lipases form versatile tools for biotechnology [J].

Jaeger, KE ;

Reetz, MT .

TRENDS IN BIOTECHNOLOGY, 1998, 16 (09) :396-403

[27] Enhancement of catalytic activity by gene truncation: Activation of L-aspartase from Escherichia coli [J].

Jayasekera, MMK ;

Saribas, AS ;

Viola, RE .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :411-414

[28] Biotransformations in the synthesis of enantiopure bioactive molecules [J].

Johnson, CR .

ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (06) :333-341

[29] Enzymatic production of ethyl (R)-4-chloro-3-hydroxybutanoate:: asymmetric reduction of ethyl 4-chloro-3-oxobutanoate by an Escherichia coli transformant expressing the aldehyde reductase gene from yeast [J].

Kataoka, M ;

Rohani, LPS ;

Yamamoto, K ;

Wada, M ;

Kawabata, H ;

Kita, K ;

Yanase, H ;

Shimizu, S .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 1997, 48 (06) :699-703

[30]

KAZLAUSKAS RJ, 1998, BIOTRANSFORMATION, V1, P37

← 1 2 3 4 5 6 7 →