The potential for Toll-like receptors to collaborate with other innate immune receptors

被引：98

作者：

Mukhopadhyay, S ^{[1
]}

Herre, J ^{[1
]}

Brown, GD ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNOLOGY | 2004年 / 112卷 / 04期

基金：

英国惠康基金;

关键词：

innate immunity; TLRs;

D O I：

10.1111/j.1365-2567.2004.01941.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.

引用

页码：521 / 530

页数：10

共 73 条

[1] Toll-like receptors in the induction of the innate immune response [J].

Aderem, A ;

Ulevitch, RJ .

NATURE, 2000, 406 (6797) :782-787

[2] Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition [J].

Akashi, S ;

Nagai, Y ;

Ogata, H ;

Oikawa, M ;

Fukase, K ;

Kusumoto, S ;

Kawasaki, K ;

Nishijima, M ;

Hayashi, S ;

Kimoto, M ;

Miyake, K .

INTERNATIONAL IMMUNOLOGY, 2001, 13 (12) :1595-1599

[3] Toll-like receptor signaling [J].

Akira, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38105-38108

[4] Role of adapters in Toll-like receptor signalling [J].

Akira, S ;

Yamamoto, M ;

Takeda, K .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :637-642

[5] Membrane proteins with immunoglobulin-like domains - a master superfamily of interaction molecules [J].

Barclay, AN .

SEMINARS IN IMMUNOLOGY, 2003, 15 (04) :215-223

[6] How we detect microbes and respond to them: the Toll-like receptors and their transducers [J].

Beutler, B ;

Hoebe, K ;

Du, X ;

Ulevitch, RJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 74 (04) :479-485

[7] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[8] Dectin-1 mediates the biological effects of β-glucans [J].

Brown, GD ;

Herre, J ;

Williams, DL ;

Willment, JA ;

Marshall, ASJ ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1119-1124

[9] Immune recognition -: A new receptor for β-glucans [J].

Brown, GD ;

Gordon, S .

NATURE, 2001, 413 (6851) :36-37

[10] The role of complement and complement receptors in induction and regulation of immunity [J].

Carroll, MC .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :545-568

← 1 2 3 4 5 6 7 8 →