The potential for Toll-like receptors to collaborate with other innate immune receptors

被引：98

作者：

Mukhopadhyay, S ^{[1
]}

Herre, J ^{[1
]}

Brown, GD ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNOLOGY | 2004年 / 112卷 / 04期

基金：

英国惠康基金;

关键词：

innate immunity; TLRs;

D O I：

10.1111/j.1365-2567.2004.01941.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of the innate immune system express a large repertoire of germ-line encoded cell-surface glycoprotein receptors including Toll-like receptors (TLRs). TLRs recognize conserved motifs on microbes and induce inflammatory signals. Evidence suggests that individual members of the TLR family or other non-TLR surface antigens either physically or functionally interact with each other and cumulative effects of these interactions instruct the nature and outcome of the immune response to a particular pathogen.

引用

页码：521 / 530

页数：10

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