Activity of Posaconazole and Other Antifungal Agents against Mucorales Strains Identified by Sequencing of Internal Transcribed Spacers

被引：66

作者：

Alastruey-Izquierdo, Ana ^{[1
]}

Victoria Castelli, Maria ^{[1
]}

Cuesta, Isabel ^{[1
]}

Monzon, Araceli ^{[1
]}

Cuenca-Estrella, Manuel ^{[1
]}

Luis Rodriguez-Tudela, Juan ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Micol, Majadahonda 28220, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 04期

关键词：

CUNNINGHAMELLA-BERTHOLLETIAE INFECTION; IN-VITRO SUSCEPTIBILITIES; AMPHOTERICIN-B; INOCULUM PREPARATION; MURINE MODEL; ZYGOMYCOSIS; THERAPY; MUCORMYCOSIS;

D O I：

10.1128/AAC.01467-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antifungal susceptibility profiles of 77 clinical strains of Mucorales species, identified by internal transcribed spacer sequencing, were analyzed. MICs obtained at 24 and 48 h were compared. Amphotericin B was the most active agent against all isolates, except for Cunninghamella and Apophysomyces isolates. Posaconazole also showed good activity for all species but Cunninghamella bertholletiae. Voriconazole had no activity against any of the fungi tested. Terbinafine showed good activity, except for Rhizopus oryzae, Mucor circinelloides, and Rhizomucor variabilis isolates.

引用

页码：1686 / 1689

页数：4

共 30 条

[1] Comparative evaluation of two different methods of inoculum preparation for antifungal susceptibility testing of filamentous fungi [J].

Aberkane, A ;

Cuenca-Estrella, M ;

Gomez-Lopez, A ;

Petrikkou, E ;

Mellado, E ;

Monzón, A ;

Rodriguez-Tudela, JL .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 (05) :719-722

[2] Prevalence and susceptibility testing of new species of Pseudallescheria and Scedosporium in a collection of clinical mold isolates [J].

Alastruey-Izquierdo, Ana ;

Cuenca-Estrella, Manuel ;

Monzon, Araceli ;

Rodriguez-Tudela, Juan L. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (02) :748-751

[3] In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents [J].

Almyroudis, Nikolaos G. ;

Sutton, Deanna A. ;

Fothergill, Annette W. ;

Rinaldi, Michael G. ;

Kusne, Shimon .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) :2587-2590

[4] Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi [J].

Cuenca-Estrella, M ;

Gomez-Lopez, A ;

Mellado, E ;

Buitrago, MJ ;

Monzon, A ;

Rodriguez-Tudela, JL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (03) :917-921

[5] Efficacy of antifungal therapy in a nonneutropenic murine model of zygomycosis [J].

Dannaoui, E ;

Mouton, JW ;

Meis, JFGM ;

Verweij, PE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (06) :1953-1959

[6] In vitro susceptibilities of zygomycetes to conventional and new antifungals [J].

Dannaoui, E ;

Meletiadis, J ;

Mouton, JW ;

Meis, JFGM ;

Verweij, PE .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (01) :45-52

[7]

de Hoog G., 1995, ATLAS CLIN FUNGI, P380

[8] In vitro susceptibility of clinical isolates of Zygomycota to amphotericin B, flucytosine, itraconazole and voriconazole [J].

Gómez-López, A ;

Cuenca-Estrella, M ;

Monzón, A ;

Rodriguez-Tudela, JL .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (06) :919-921

[9] A murine model of zygomycosis by Cunninghamella bertholletiae [J].

Honda, A ;

Kamei, K ;

Unno, H ;

Hiroshima, K ;

Kuriyama, T ;

Miyaji, M .

MYCOPATHOLOGIA, 1998, 144 (03) :141-146

[10] Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole [J].

Imhof, A ;

Balajee, SA ;

Fredricks, DN ;

Englund, JA ;

Marr, KA .

CLINICAL INFECTIOUS DISEASES, 2004, 39 (05) :743-746

← 1 2 3 →