In pursuit of carbohydrate-based HIV vaccines, Part 2: The total synthesis of high-mannose-type gp120 fragments-evaluation of strategies directed to maximal convergence

被引：102

作者：

Geng, XD

Dudkin, VY

Mandal, M

Danishefsky, SJ

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期

关键词：

antigens; glycoconjugates; glycopeptides; mannosylation; total synthesis;

D O I：

10.1002/anie.200353626

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A layered approach" and a "block approach" were used to assemble the high-mannose glycan of gp120 glycopeptide fragments (e.g. high-mannose-type conjugates gp120316-3351). The glycan was then conjugated with the gp120 peptide segments through direct aspartylation."

引用

收藏

页码：2562 / 2565

页数：4

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